Renal PKC epsilon deficiency attenuates acute kidney injury and ischemic allograft 1 injury via TNF alpha dependent inhibition of apoptosis and inflammation
نویسندگان
چکیده
1 injury via TNF alpha dependent inhibition of apoptosis and inflammation 2 3 Song Rong, Katja Hueper, Torsten Kirsch, Robert Greite, Christian Klemann, Michael 4 Mengel, Matthias Meier, Jan Menne, Michael Leitges, Nathan Susnik, Martin Meier, 5 Hermann Haller, Nelli Shushakova, Faikah Gueler 6 7 8 Correspondence to: 9 Prof. Faikah Gueler, 10 Department of Nephrology 11 Medical School Hannover, 12 Carl-Neuberg-Str.1, 30625 Hannover, 13 Tel: 0049-511-532 3722, Fax: 0049-511-552366 14 email: [email protected] 15 16 Department of Nephrology, Hannover Medical School, Hannover, Germany 17 Phenos GmbH, Hannover, Germany 18 The Transplantation Center of the affiliated hospital, Zunyi Medical College, China 19 Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, 20 Canada 21 The Biotechnology Centre of Oslo, University of Oslo 22 Institute for Diagnostic and Interventional Radiology, Medical School Hannover, Hannover, 23 Germany 24 Articles in PresS. Am J Physiol Renal Physiol (July 23, 2014). doi:10.1152/ajprenal.00372.2013
منابع مشابه
Renal PKC-ε deficiency attenuates acute kidney injury and ischemic allograft injury via TNF-α-dependent inhibition of apoptosis and inflammation.
Acute kidney injury (AKI) increases the risk of morbidity and mortality after major surgery and transplantation. We investigated the effect of PKC-ε deficiency on AKI and ischemic allograft damage after kidney transplantation. PKC-ε-deficient and wild type (WT) control mice were subjected to 35 min of renal pedicle clamping to induce AKI. PKC-ε deficiency was associated with a marked improvemen...
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